Home Stories This wonderful breakthrough in preventing dengue is withdrawing

This wonderful breakthrough in preventing dengue is withdrawing

In relation to killing people, no different animal—not sharks, snakes, or crocodiles—is as lethal because the mosquito.

However within the struggle in opposition to dengue fever, one sort of mosquito has been remodeled right into a surprisingly highly effective ally to avoid wasting and enhance lives.

Dengue fever is a virus unfold by way of bites by the Aedes aegypti mosquito. Nicknamed “breakbone fever” due to the extreme ache it causes, dengue infects about 400 million individuals yearly and kills greater than 20,000. Warming temperatures resulting from local weather change have expanded the geographic vary of the mosquitoes, driving up the variety of dengue instances in recent times.

Researchers with the World Mosquito Program, nonetheless, have been engaged on a breakthrough that simply may defeat dengue for good.

This breakthrough depends on a tiny bacterium known as Wolbachia and the Aedes aegypti mosquito.


Wolbachia is a standard and innocent bacterium present in 60 p.c of all bugs, together with fruit flies, bees, moths, and butterflies. However it’s not present in Aedes aegypti mosquitoes. Greater than a decade in the past, researchers made a shocking discovery about Wolbachia. If Wolbachia is given to Aedes aegypti mosquitoes, it blocks them from transmitting the dengue virus. Researchers discovered that Wolbachia spreads quickly amongst mosquitoes once they mate, blocking the unfold of dengue from one technology of mosquitoes to the following.

All this preliminary analysis was accomplished in a lab setting. The subsequent step was to check whether or not this strategy would work in the actual world. If Wolbachia mosquitoes had been launched right into a group, wouldn’t it result in a discount in dengue instances?

That’s the experiment the World Mosquito Program, a non-profit working to cease the unfold of dengue and different mosquito-borne illnesses, has been conducting in Yogyakarta, Indonesia. (Our basis has been a proud funder of this analysis. In 2014, I visited Yogyakarta to see this work simply because it was getting began. I even helped feed a number of the Wolbachia-carrying mosquitoes!)

As a part of a randomized managed trial, researchers launched Wolbachia mosquitoes in elements of Yogyakarta, which has a number of the highest charges of dengue fever within the nation.

Setting mosquitoes free in individuals’s neighborhoods is, after all, an unconventional resolution to struggle dengue. To earn public belief, researchers collaborated intently with the area people. They met with 1000’s of individuals within the metropolis and addressed their questions and considerations about this system.

This public outreach effort took years. However it was value it.

In June, the New England Journal of Medication published the results of the trial, which present that the Wolbachia-carrying mosquitoes diminished the variety of dengue instances by 77 p.c and dengue hospitalizations by 86 p.c.

Now, the World Mosquito Program is working to increase this effort in different elements of the world the place dengue is a menace, together with cities in Sri Lanka, Vietnam, Brazil, Colombia, Mexico, Australia, and Fiji.

This effort could be efficient in stopping not solely dengue, but additionally Zika, yellow fever, and different illnesses transmitted by Aedes aegypti mosquitoes.

It’s laborious to overstate the influence the World Mosquito Program might have on communities liable to these illnesses. Each greenback spent on this effort is anticipated to ship $4 in financial advantages by saving billions of {dollars} in well being care prices and stopping billions of hours of misplaced productiveness resulting from sickness.

I sit up for sharing extra information about this unbelievable venture within the years forward.

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